CAR T-Cell Therapy Offers Hope for Relapsed Multiple Myeloma
Multiple myeloma (MM) impacts around 35,000 new patients annually in the United States, with over 12,000 deaths. Advances in treatments like proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies...
CURATED BY: Laura J. Zitella, MS, RN, ACNP-BC, AOCN
MS, RN, ACNP-BC, AOCN
Nurse Practitioner, Associate Clinical Professor, University of California San Francisco
Rare Multiple Myeloma Case in Pregnancy Successfully Managed With Treatment, Leading to Healthy Delivery
Multiple myeloma (MM) during pregnancy is rare, with only 45 cases reported between 1965 and 2020. In the presented case, a 40-year-old woman was diagnosed with oligosecretory IgG kappa MM...
Managing Multiple Myeloma: Addressing Bone Disease and Improving Treatment Options for Older Adults
Multiple myeloma (MM) is a cancer of clonal plasma cells primarily affecting older adults, with approximately 35,000 new cases annually in the United States. Advances in treatment, including immunomodulatory drugs,...
Tailoring CAR-T Therapy for Older Adults: Addressing Frailty and Improving Outcomes
CAR-T therapy has been effective in treating relapsed/refractory hematologic cancers like multiple myeloma and diffuse large B-cell lymphoma, especially in older adults. However, its use in patients aged 75 and...
Efficacy of Daratumumab Regimens in Transplant-Eligible Patients With NDMM With High-Risk Cytogenetic Abnormalities
The MASTER study (NCT03224507) and GRIFFIN study (NCT02874742) evaluated the efficacy of daratumumab-containing regimens in transplant-eligible newly diagnosed patients with multiple myeloma (NDMM) with high-risk cytogenetic abnormalities (HRCAs)....
Advanced BCMA-Targeted Therapies Promise New Hope for Incurable Multiple Myeloma
Despite significant advancements in multiple myeloma (MM) treatment, MM remains largely incurable, particularly for relapsed or refractory cases. The focus on B-cell maturation antigen (BCMA) as a target has shifted...