Early mortality (EM) is a concern in hematologic malignancies, including multiple myeloma (MM), where mortality rates remain high within the first two years of diagnosis. Despite advances in treatment over the past 20 years, a significant portion of patients with MM experience EM, with rates reaching up to 20% within the first six months. Contributing factors to EM include older age, male sex, lower income, and minority status, particularly among those who are non-Hispanic Black (NHB) and Hispanic. 

Using data from the SEER registry (2000-2019), researchers analyzed 77,374 patients with MM to assess the impact of sociodemographic factors on EM. The study found that minorities, especially those who are NHB and Hispanic, had higher odds of experiencing EM compared to non-Hispanic White patients, with income influencing survival but not eliminating racial disparities. The study emphasizes the need for tailored interventions for minority groups and increased representation in clinical trials to address these disparities. Efforts to improve EM outcomes may include addressing biologic differences and promoting equitable access to new treatments and early interventions.

Reference: Wei JX, Shastri A, Sica RA, et al. Impact of race and ethnicity on early mortality in multiple myeloma: a SEER analysis. Haematologica. 2024;109(5):1480-1486. doi: 10.3324/haematol.2023.283304.