The International Myeloma Working Group, National Comprehensive Cancer Network (NCCN), and European Hematology Association and European Society for Medical Oncology (EHA-ESMO) worked to set forth guidelines that recommend the following diagnostic studies for multiple myeloma: serum and urine assessment for monoclonal protein, serum free light chain (FLC) assay, bone marrow aspiration and/or biopsy, and more.