The MASCOT cohort study explores the influence of physical activity and fitness on the quality of life, bone health, and fatigue in patients with multiple myeloma (MM). It evaluates patients in the plateau phase of MM, tracking their physical activity, fitness, bone health, and fatigue at baseline and then at 3, 6, and 12 months. Clinical health markers, psychological and physical well-being, and lifestyle behaviors will be assessed using objective measures such as cardiopulmonary exercise testing (CPET) and accelerometers, as well as self-report questionnaires. It will also identify the stages in the MM treatment process where physical activity interventions could be most beneficial.

This study is crucial in understanding the role of physical activity in the recovery and quality of life of MM patients. Findings from the MASCOT study provide valuable insights into developing tailored exercise interventions and lifestyle recommendations for MM patients, potentially improving their long-term health outcomes and quality of life.

Reference: Heinrich M, Fisher A, Paton B, et al. Lifestyle in Multiple Myeloma – a longitudinal cohort study protocol. BMC Cancer. 2016 Jul 4;16:387. doi: 10.1186/s12885-016-2407-x. PMID: 27377407; PMCID: PMC4932746.