There are multiple options available for the detection of bone and bone marrow lesions, ranging from conventional skeletal survey to whole-body CT, PET-CT, and MRI. The International Myeloma Working Group published guidelines on optimal use of imaging methods at different disease stages.

Reference: Hillengass J, Usmani S, et al. Oncology, International myeloma working group consensus recommendations on imaging in monoclonal plasma cell disorders. The Lancet. 2019.