Treatment

FDA ODAC Backs Ide-Cel in Multiple Myeloma, Highlighting KarMMa-3 Trial Results

The FDA Oncologic Drugs Advisory Committee (ODAC) voted 8 to 3 in favor of using intravenous infusion of idecabtagene vicleucel (ide-cel; Abecma) for patients with pretreated relapsed/refractory multiple...
CURATED BY: Laura J. Zitella,
MS, RN, ACNP-BC, AOCN

DREAMM-8 Trial: Belantamab Mafodotin Shows Promise in Treating Multiple Myeloma

GSK, the manufacturer of the antibody-drug conjugate belantamab mafodotin-blmf (Blenrep), has announced positive top-line findings from the phase 3 DREAMM-8 trial for belantamab mafodotin combined with pomalidomide and dexamethasone in...
CURATED BY:
Laura J. Zitella,
MS, RN, ACNP-BC, AOCN

FDA Panel Backs Cilta-cel for Relapsed/Refractory Multiple Myeloma Post-CARTITUDE-4 Success

The FDA’s Oncologic Drugs Advisory Committee unanimously voted that ciltacabtagene autoleucel (cilta-cel; Carvykti) offers more benefits than risks for treating adult patients with relapsed/refractory multiple myeloma who have had at...
CURATED BY:
Laura J. Zitella,
MS, RN, ACNP-BC, AOCN

SHIVERING 2 Trial Shows Tandem High-Dose Influenza Vaccines Significantly Improve Protection in Plasma Cell Dyscrasia Patients

Plasma cell dyscrasias (PCDs), like multiple myeloma, are hematologic disorders that lead to compromised immune responses, making vaccinations, particularly against influenza, less effective in patients with PCDs due to their...
CURATED BY:
Jill N. Burke,
CNP, DipACLM

Study Highlights Age-Related Treatment Outcomes in Myeloma, Underscores Need for Personalized Approaches

A study assessed treatments for myeloma, noting advancements in patient outcomes due to proteasome inhibitors and immunomodulatory drugs, yet acknowledging persistently poor results in high-risk cases marked by rapid disease...
CURATED BY:
Jill N. Burke,
CNP, DipACLM

Study Shows Denosumab Outperforms Zoledronic Acid in Treating Bone Metastasis in Advanced Cancer

Researchers evaluated the efficacy and safety of denosumab compared to zoledronic acid in treating advanced cancer with bone metastasis. Extensive literature searches in MEDLINE, EMBASE, and the Cochrane library databases...
CURATED BY:
Jill N. Burke,
CNP, DipACLM

Study Compares CAR-T Therapy Evolution to Ford Model T’s Impact: Revolutionizing Multiple Myeloma Treatment

Researchers drew an analogy between the evolution of chimeric antigen receptor T-cell (CAR-T) therapy for plaque psoriasis (PsO) and the historical development of the Ford Model T, highlighting the transformative...
CURATED BY:
Jill N. Burke,
CNP, DipACLM
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